CONTRAINDICATIONS
NUCALA should not be administered to patients with a history of hypersensitivity to mepolizumab or excipients in the formulation.

...CONTINUED BELOW

Patients 12 years of age and older with severe asthma who have:


A 32-week clinical study of 576 patients evaluated frequency of exacerbations in patients treated with NUCALA compared with patients receiving placebo.

Exacerbations of asthma were defined as the worsening of asthma that required use of oral/systemic corticosteroids and/or hospitalization and/or emergency department (ED) visits; for patients requiring maintenance oral/systemic corticosteroids, exacerbations were defined as at least double the existing maintenance dose for at least 3 days"toolbar=yes, scrollbars=yes, resizable=yes, width=400, height=400,top=50, left=50"8

 

Identifying patients with applicable blood eosinophil counts

Multiple cell types, including eosinophils, are involved in inflammation."toolbar=yes, scrollbars=yes, resizable=yes, width=400, height=400,top=50, left=50"7 Recent findings suggest blood eosinophil level can be used as a biomarker to guide therapy in severe asthma."toolbar=yes, scrollbars=yes, resizable=yes, width=400, height=400,top=50, left=50"6 Blood eosinophil count is a common measure as part of the complete blood count (CBC) with differential test."toolbar=yes, scrollbars=yes, resizable=yes, width=400, height=400,top=50, left=50"6

Patient Profile

Do you recognize Anthony?"toolbar=yes, scrollbars=yes, resizable=yes, width=400, height=400,top=50, left=50"

Age: 37
Height: 5'9"
Weight:
195 lbs
Diagnosed with asthma: 25 years ago
Eosinophils: ≥150 cells/μL within 6 weeks of initiation of dosing
Current therapy: High-dose maintenance inhaled corticosteroid/long-acting beta2agonist (ICS/LABA) and intermittent bursts of oral corticosteroids (OCS)
GINA classification: Step 5 if he remains uncontrolled on Step 4"toolbar=yes, scrollbars=yes, resizable=yes, width=400, height=400,top=50, left=50"9
Anthony is a high school guidance counselor who is married with 1 child.

Hypothetical patient profile. Not intended to represent all patients."toolbar=yes, scrollbars=yes, resizable=yes, width=400, height=400,top=50, left=50"8
Primary clinical concern: Anthony had 2 asthma exacerbations in the past year that led to emergency department (ED) visits (1 in which he was given high-dose OCS before discharge and 1 that resulted in hospitalization). He is frustrated about his current asthma symptoms and worried about future exacerbations requiring hospitalization

GINA=Global Initiative for Asthma.

   818521R0 April 2017